# 1 Brand for Brain Health
TikTok Viral
Informed by 300,000+ Brain Scans
Clinical-Grade
Third-Party Tested
# 1 Brand for Brain Health
TikTok Viral
Informed by 300,000+ Brain Scans
Clinical-Grade
Third-Party Tested
# 1 Brand for Brain Health
TikTok Viral
Informed by 300,000+ Brain Scans
Clinical-Grade
Third-Party Tested
# 1 Brand for Brain Health
TikTok Viral
Informed by 300,000+ Brain Scans
Clinical-Grade
Third-Party Tested
Happy Saffron Plus
3-in-1 doctor-developed formula for improved mood, memory, and libido*
- Lift your mood, naturally – Clinically studied saffron supports emotional balance and mental wellness without harsh side effects*
- Sharpen your memory and focus – Longvida® curcumin is shown to improve working memory and cognitive performance*
- Revive your desire – Zinc and saffron work together to support healthy libido and sexual function*
- Reduce occasional anxiousness – Helps regulate key brain chemicals like serotonin, dopamine, and BDNF for a calmer, more resilient mind*
- Doctor-developed, clinically validated – Created by Dr. Daniel Amen and backed by 25+ human clinical studies*
HAPPY BRAIN, HEALTHY BODY'
Better Mood, Memory & Sexual Health*
Happy Saffron Plus® isn’t just doctor-developed, it's doctor-recommended, loved in 217 countries, and backed by over 25 human studies.*
In the largest clinical trial on saffron and mood to date, 72% of participants taking affron® (the exact extract in this formula) experienced meaningful mood improvement, many in just 5 weeks.*
With Longvida® curcumin for focus and memory, plus zinc glycinate for mood and sexual health, this 3-in-1 formula delivers fast, feel-good results - naturally.*
Daniel G. Amen, MD
FOUNDER & CHIEF VISIONARY OFFICER, BRAINMD
Dr. Daniel Amen is a double board-certified psychiatrist, 20-time national bestselling author, and one of the most influential voices in brain health. He’s the founder of Amen Clinics, home to the world’s largest database of brain scans related to behavior, with over 300,000 scans and counting.
Through his groundbreaking research, bestselling books, and BrainMD’s doctor-developed supplements, Dr. Amen has helped millions improve their memory, mood, focus, and mental well-being.
Expert Reviews
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Dr. Daniel Amen
Founder, BrainMD & Amen Clinics
"This is one of my favorite formulas. Saffron has been studied for centuries, but the form we use—affron®—is backed by modern clinical trials. I take Happy Saffron Plus® daily because it works. Better mood, better memory, better overall brain health—naturally."
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Dr. Jonny Bowden PhD, CNS
Board Certified Nutrition Specialist
"This formula contains ingredients I used to recommend individually but BrainMD combines them in clinically validated doses for even better results. I’ve seen it help patients feel more emotionally balanced and mentally sharp within weeks." -
Peggy Perez
Brain Health Professional, NASM CPT & CES, IIS Health Coach
"Saffron has long been used in ancient medicine, but affron® takes it to a new level. It’s clinically backed, bioavailable, and when paired with Longvida® curcumin and zinc glycinate, it becomes a powerhouse for brain health and emotional wellness."
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Erica Williams
Brain Health Professional, Elite Brain Health Coach, Life Coaching & Consulting Associates
"I love Happy Saffron Plus®! I was able to be off all anxiety/depression medications after 23 years. It works on multiple levels—mood, focus, and energy. It’s NAME-developed, rooted in science, and something I recommend regularly to my clients."
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#1 For Brain Health
Backed by 30+ years of research, 60+ MDs & 300,000+ brain scans.*
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Doctor-Recommended
Formulated by Dr. Daniel Amen and leading brain health experts.
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Clinically Backed
Clinically studied ingredients. Backed by science. Proven to work.
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HSA/FSA Eligible
Use pre-tax dollars to support your brain, body, and daily health.
FAQ
HOW DO I TAKE HAPPY SAFFRON PLUS®?
HOW DO I TAKE HAPPY SAFFRON PLUS®?
It’s recommended that adults take 3 capsules daily between meals.*
CAN CHILDREN TAKE HAPPY SAFFRON PLUS®?
CAN CHILDREN TAKE HAPPY SAFFRON PLUS®?
Children ages 4-18 years can take 1 capsule per 40 pounds body weight, maximum 3 capsules daily.*
IS HAPPY SAFFRON PLUS® SUITABLE FOR VEGANS?
IS HAPPY SAFFRON PLUS® SUITABLE FOR VEGANS?
Yes. Happy Saffron Plus® is suitable for vegans, especially those seeking to improve their mood.*
IS IT POSSIBLE TO GET HOOKED ON THIS PRODUCT?
IS IT POSSIBLE TO GET HOOKED ON THIS PRODUCT?
As with other BrainMD products, this is a dietary supplement, not a drug.* It isn’t habit-forming.*
DOES THIS SUPPLEMENT CONTAIN ALLERGENS?
DOES THIS SUPPLEMENT CONTAIN ALLERGENS?
It is free from dairy, gluten, sugar, corn, nuts, eggs, yeast, and artificial flavorings or colorings.* It does contain very small levels of soy (non-GMO).*
Customer Reviews
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Game Changer
Better than any SSRIs, it makes you happy and it helps you deal with the every day stress.
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It truly works!
Product really works. I give it to my pre-teen daughter whenever she wakes up feeling stressed or angry for no apparent reason and pills help her calm her brain down and changes her mood to a more relaxed and happy state.
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Finding Relief During Menopause
Pre-menopause, we may think that we have a hard time with fluctuating hormones. The world changes again with the onset of menopause. Happy Saffron has helped stabilize my day and I don't have nearly the ups and downs that I did before.
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Feel good supplement
I always feel calmer and a slight elevation into happiness without feeling high. I'm really loving Happy Saffron Plus.
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Very Pleased
I have been taking Happy Saffron Plus a little less than a month and I can't wait to get my next bottle. I am prone to depression and my outlook on life and my mood has improved since beginning Happy Saffron Plus. Thank you for this wonderful product.
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Happy little pill
Like any good thing - it doesnt happen overnight. Stick to the labeled way of taking these pills and you will see a difference.
